Magnetic Resonance Imaging (MRI) has an enormous potential as a tool for study of neurophysiology in humans in vivo. We are developing new MRI methods and applying these and existing MRI methods specifically to study the neurovascular coupling in healthy subjects and patients with neurovascular and neurodegenerative diseases, such as stroke, migraine and other pain related diseases, multiple sclerosis and optic neuritis. Perfusion methods comprise T1 and T2 weighted contrast enhanced dynamic imaging and arterial spin labelling, which does not employs contrast injection. Cerebral activation studies are performed when using Blood Oxygenation Level Dependent (BOLD) imaging together with T1 perfusion.

A major topic is simultaneous electroencephalographical recordings and BOLD imaging, with the aim to investigate possible correlations of neural synaptic activity and hemodynamic changes during cerebral activation. We also study modulation of neurovascular coupling by various pharmacological substances. Finally, we use MRI methods to monitor the efficacy of new treatment in various diseases.

P.h. D. Course

LUCENS has decided to develop a Ph.D. course in Neurovascular Signaling. This has been delayed because we first tried to associate it with a Ph.D. course at the Graduate School of Neuroscience, but the whole structure of Ph.D. schools of the University of Copenhagen was revised.
We are now planning an independent Ph.D.course in neurovascular Signaling.