Migraine is the most prevalent neurological disorder affecting at any one time 10% of the adult population. It has a large unmet need for better treatments and its mechanisms are incompletely understood although clearly in the realm of neuroscience. The group focuses specifically on the identification of new mechanisms of migraine that are possible novel targets for migraine drugs. We do this by several different approaches. Most importantly, we study normally occurring signaling molecules for their ability to induce headache and migraine in volunteer normal subjects or migraine patients. Substances that can induce headache/migraine are then investigated in our animal models in order to learn about their activity in different tissues relevant to migraine: Blood vessels, perivascular nerves, trigeminal ganglion, trigeminal nucleus as well as higher pain centers. In animal experiments we also analyze subtypes of receptors/ion channels that are most relevant for migraine. Furthermore, we study neurovascular reactions in humans after intravenous infusion of signaling molecules relevant to migraine and use for this several different techniques. Most important are a number of MR techniques, transcranial Doppler, high frequency ultrasound imaging and near-infrared spectroscopy. So far our research has greatly contributed to the development of nitric oxide (NO) related targets, calcitonin gene-related peptide targets and cortical spreading depression related targets. In current research we focus on peptide neuro-transmittors, ion channels and protanoids.